SWISS-PROT database
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The SWISS-PROT database is a curated biological database of protein sequences and associated information, maintained by the Swiss Institute of Bioinformatics (SIB). It is one of the most widely used protein sequence databases and is particularly popular among researchers in the field of bioinformatics.
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The SWISS-PROT database contains a comprehensive collection of protein sequences from a wide range of organisms, including bacteria, fungi, plants, animals, and viruses. Each protein sequence in the database is carefully annotated with information such as protein name, function, subcellular localization, post-translational modifications, and references to relevant research articles.
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Unlike many other protein sequence databases, which rely on automated methods for annotation, the SWISS-PROT database is manually curated, meaning that expert biologists review and verify the annotation for each sequence. This ensures a high degree of accuracy and reliability in the information contained in the database.
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Researchers use the SWISS-PROT database for a wide range of purposes, such as:
Identifying and obtaining protein sequences of interest for their research
Comparing and analyzing protein sequences to understand their function and evolutionary history
Discovering new protein variants and mutations associated with diseases or other traits
Developing and testing computational tools for protein sequence analysis and annotation
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The SWISS-PROT database is freely accessible to researchers around the world and can be searched and downloaded through the ExPASy website, which is also maintained by the SIB. The database also provides a variety of tools and resources for protein sequence analysis, annotation, and visualization.
In addition to the SWISS-PROT database, the SIB maintains several other biological databases, such as UniProtKB/Swiss-Prot, which is an updated version of SWISS-PROT, and UniProtKB/TrEMBL, which contains computationally predicted protein sequences. These databases complement and interconnect with SWISS-PROT to provide a comprehensive resource for researchers in the life sciences.
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Tags
Bioinformatics